Blog Posts
September 16, 2022

Breast Cancer through LARVOL Eyes

Blog Posts
September 16, 2022

Breast Cancer through LARVOL Eyes

Author

This October, we are recognizing Breast Cancer Awareness Month with three very different takes on breast cancer from our organization and the Tigers who make us who we are.

At LARVOL, we've chosen oncology as our strategic company focus.

We understand the enormous impact of cancer on so many around the world, and we’re committed to helping to ease that burden. This October, we’re adding our voice as a company--and the voices of a few of our Tiger team—to support Breast Cancer Awareness Month.  

As an organization, we see breast cancer most clearly through data.

We know that breast cancer is the most common cancer impacting Americans today, followed by prostate and lung cancer. We know that one out of eight women, and one out of 833 men in the U.S. will face a breast cancer diagnosis during their lifetime; the stats are similar around the world. To date, there have been 110 genes identified as associated with breast cancer, and only 5-10% of those are hereditary.  

There’s an enormous amount of data emerging every day in the area of breast cancer research, from trial data to drug approvals and much, much more. At LARVOL, we are the intake team for all this data, triaging what’s important, organizing it, and getting it to the experts who can use it to make a difference for patients and their families. Our customers rely on us to deliver what’s new in breast cancer data to them with speed and precision, so that they can use it to make strategic decisions around clinical trials and drug development.

But we know, of course, that breast cancer is not just a data set.

Through the eyes of someone battling breast cancer, it’s not just genes or mutations or hormone receptors.   It’s fear. It’s waiting…for results and treatments to work.  It’s anxiety.  It’s an uncertain future.

Two of our own Tigers faced this reality in the past year and have agreed to share how they see breast cancer through their own eyes.  

First up, Aviva Fridman (VP, Operations):

Before 2020, I experienced breast cancer in several different ways. I saw cancer through the eyes of a researcher. While working with vials of blood and tissue samples.  I didn’t often see a person behind the data. I was looking to contribute to the pool of breast cancer information, in the hopes that it would lead to earlier detection. I’ve also seen breast cancer through the eyes of a granddaughter, a daughter, a friend, and a colleague.

Last year, however, I saw breast cancer through the eyes of a patient. Nothing prepared me for that--not my background in oncology research, nor my work at LARVOL. The results from biopsies and surgeries never came fast enough. The treatment options seemed dated, and barbaric.  

On the other side of my breast cancer experience I have a renewed sense of hope and dedication to my work. My hope for the future is a time when diagnosis can be done in hours, not days or weeks. I look forward to treatment options that don’t require radiation, chemotherapy and/or cutting off a body part. And I hope for a future where individual treatment plans are the norm, rather than following broad guidelines that are slow to change. I wish for a time when being diagnosed with breast cancer won’t be met with fear, uncertainty and anxiety, but with optimism and confidence.

Like Aviva, Abby Fraser (VP, Marketing), saw breast cancer through new eyes this year:

I learned more about breast cancer this year than I ever imagined I would need to learn. First, as a new member of the LARVOL team, I got a crash course in biomarkers, Kaplan-Meier Curves, and precision medicine treatments as I learned the ins and outs of our oncology products. I sat in meeting after meeting, in awe of the experts I had the pleasure of working with and learning from.  

Just as I was beginning to grasp the vocabulary of the job, the conversation moved a lot closer to home. In May, I became the daughter of a breast cancer patient. As my mom experienced appointments, tests, surgeries, and radiation treatments throughout the year, the rest of us just had to wait. I say “just” with a good measure of sarcasm, as it was the very least we could do. But it was truly a difficult task. My sisters, my dad, our partners, and colleagues, and friends. There’s no feeling quite as helpless as taking care of your mother. I simply tried to do what I thought she would do for me, and to mimic the ways she’s taken care of us all for so long.

I’m happy to report that she finished radiation treatments just before October began and that all scans are looking great! My hope for the future is to better understand the ways families and loved ones can support breast cancer patients throughout the process of diagnosis and treatment. I know the road is longer and more difficult for many, and I’m grateful to be able to see that through new eyes today.  

At LARVOL, our hope for the future of breast cancer is that the continued identification of sets of genes will provide the key to personalized treatment plans.  We envision faster integration and organization, of new information into the vast pool of data, so that treatment guidelines can be updated as new data becomes available, instead of annually as they are typically updated now. Our goal is to help make that future the reality now, so that our Tigers, their families, and women and men across the globe don’t have to panic when they hear they have been diagnosed with breast cancer.

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Not rated
Allison Betof Warner, MD, PhD (she/her) 4
3743
Manhattan, NY
November 10, 2022

79% had reduction in disease. ORR 31%. Many responses deepen over time.

Not rated
Allison Betof Warner, MD, PhD (she/her) 3
3743
Manhattan, NY
November 10, 2022

Median DOR not yet reached. Median OS 13.9 mo. 12 mo OS was 54%. As typical with immunotherapy, we see a nice tail on the curve. #TIL#SITC22

Positive
Alex Shoushtari, MD
2253
New York, USA
November 10, 2022

Important work on efficacy of TIL therapy lifileucel in PD-1 resistant #melanoma being presented at #SITC22. Pretty good durability for this heavy lift of a treatment.

Not rated
Allison Betof Warner, MD, PhD (she/her) 2
3743
Manhattan, NY
November 10, 2022

Toxicity profile was in line with prior TIL/Lifileucel data. No surprises here. Median # doses of IL-2 was 6.

Positive
Hussein Tawbi, MD, PhD
1685
Houston, TX
November 10, 2022

Absolutely agree!… this should be available to our melanoma patients ASAP!… and paves the way for smarter cellular therapies to be designed, studied, and eventually widely disseminated

Positive
Allison Betof Warner, MD, PhD (she/her) 1
3744
Manhattan, NY
November 10, 2022

Where does this leave us with #TIL therapy for #melanoma? IMO, this response rate/durability justifies accelerated approval. Pts with PD-1 refractory melanoma need options. It’s FAR from a perfect tx but provides meaningful clinical benefit. What say you melanoma Twitterverse?

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Sumanta K. Pal, MD, FASCO
15083 Followers
Los Angeles, CA
November 8, 2022

Just before I start AM clinic at @cityofhopeoc, excited to share results from #COBALT_RCC, a P1 trial of @CRISPRTX#CTX130 in #kidneycancer in the @sitcancer#PressProgram. Will present more on Thurs 5:37p at #SITC22! Thx @neerajaiims@DrBenTran@HaanenJohn#SamerSrour& co-Is! t.co/aDnhG9n92A

not rated
Shilpa Gupta
5095 Followers
Cleveland, OH
November 8, 2022
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Tian Zhang, MD, MHS
6463 Followers
Dallas, TX
November 8, 2022

CAR-Ts are coming for #kidneycancer!! Congratulations @montypal and team; can’t wait to see results at #SITC22! t.co/9MrlF2yzBe

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Moshe Ornstein MD
1930 Followers
Cleveland, OH
November 8, 2022

Congrats @montypal and team! Great to see CAR T therapy coming to #RCCt.co/ypRHBC89Pt

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Shuchi Gulati MD
12476 Followers
Seattle, WA
November 8, 2022

Another huge step from none other than @montypal!! CAR-Ts in #kidneycancer!Congratulations to the entire team!Looking forward to seeing the results at #SITC22! t.co/HvKeVBPyV7

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Petros Grivas
12476 Followers
Seattle, WA
November 8, 2022

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