Biomarker & CDx
September 13, 2021

Breakthroughs in Precision Oncology

Biomarker & CDx
August 24, 2020

Breakthroughs in Precision Oncology

Author

Let's look at some of the recent breakthroughs in precision oncology like Precision Medicine Initiative, advancements in medical imaging, and precision medications in the market.

In the past few years, precision medicine has rapidly adjusted the oncology diagnostic and treatment spectrum. Technological advances for characterizing patients’ genomic, proteomic, metabolic, and cellular profiles, in combination with the development of large biomarker databases such as Veri, along with computational tools that analyze them, have permitted clinicians to modify and adapt treatment strategies to precisely target the molecular alteration underlying each patients’ cancer.

Recent Breakthroughs

In 2015, advances  in precision medicine led to the formation of the US Precision Medicine Initiative starting at $215m and oncology was designated as the near-term focus of the Precision Medicine Initiative, guided by new knowledge of new mechanisms in cancer development and progression that have already influenced risk assessment and therapeutic strategies.

Precision Medicine Initiative#

The Precision Medicine Initiative (PMI) is a nationwide initiative to move to health care that tailors treatment and prevention strategies to people’s unique characteristics, including environment, biology and individual lifestyles.

Current activities include Sync for Science aiming to develop a simplified, scalable and secure way for patients to access their electronic health record data with researchers. Sync for Genes aims to standardize the sharing of genetic and genomic information amongst labs, providers, patients and researchers. Furthermore, there is Advancing Standards for Precision Medicine (ASPM) which is working to make health data easier to share and synthesize by focusing on standards in mobile health, sensors, and wearable data.

Medical Imaging

The global precision medical imaging market accounted for $4.5 billion in 2019 and is estimated to grow to $9.0 billion by 2029. In the new era of precision medicine in oncology medical imaging is pivotal for a wide spectrum of indications from early detection of malignant tumours or lesions, to response assessment in advanced metastatic disease.

Currently, there are thousands of life sciences companies about to, or who already have assay tests, known as molecular profiling and diagnostics which sequence a tumour for DNA, RNA and proteins for a wide variety of biomarkers.

Marketing Precision Medications

The global precision medicine market witnessed a compound annual growth rate (CAGR) of 9.7% with the prime factors propelling the growth of this market coming from increasing online collaborative forums, increasing efforts to characterize genes, and advancements in cancer biology.

Never underestimate the importance of market research as research will drive the business by giving you formal insights into what oncologists and customers are in need of and are willing to pay.

In order for doctors and oncologists to both fully understand and utilise the correct treatments in cancer it is vital for them to have a solid space examining the sheer number of biomarkers and their responses to drugs. There still, in this way, remains the choice of which database or company would ideally provide the most beneficial data as well as knowing the quality of the company’s data curation.

Veri

Veri is a data platform to link predictive biomarkers in oncology and drug response. The database was created by a global team of expert analysts at Larvol, a technology company with 15 years of experience in data curation for the pharmaceutical and biotechnology industry. The goal of Veri is to become the most broad and relied upon tool for physicians, researchers and industry leaders who are involved in precision medicine.

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Not rated
Allison Betof Warner, MD, PhD (she/her) 4
3743
Manhattan, NY
November 10, 2022

79% had reduction in disease. ORR 31%. Many responses deepen over time.

Not rated
Allison Betof Warner, MD, PhD (she/her) 3
3743
Manhattan, NY
November 10, 2022

Median DOR not yet reached. Median OS 13.9 mo. 12 mo OS was 54%. As typical with immunotherapy, we see a nice tail on the curve. #TIL#SITC22

Positive
Alex Shoushtari, MD
2253
New York, USA
November 10, 2022

Important work on efficacy of TIL therapy lifileucel in PD-1 resistant #melanoma being presented at #SITC22. Pretty good durability for this heavy lift of a treatment.

Not rated
Allison Betof Warner, MD, PhD (she/her) 2
3743
Manhattan, NY
November 10, 2022

Toxicity profile was in line with prior TIL/Lifileucel data. No surprises here. Median # doses of IL-2 was 6.

Positive
Hussein Tawbi, MD, PhD
1685
Houston, TX
November 10, 2022

Absolutely agree!… this should be available to our melanoma patients ASAP!… and paves the way for smarter cellular therapies to be designed, studied, and eventually widely disseminated

Positive
Allison Betof Warner, MD, PhD (she/her) 1
3744
Manhattan, NY
November 10, 2022

Where does this leave us with #TIL therapy for #melanoma? IMO, this response rate/durability justifies accelerated approval. Pts with PD-1 refractory melanoma need options. It’s FAR from a perfect tx but provides meaningful clinical benefit. What say you melanoma Twitterverse?

Not Rated
Sumanta K. Pal, MD, FASCO
15083 Followers
Los Angeles, CA
November 8, 2022

Just before I start AM clinic at @cityofhopeoc, excited to share results from #COBALT_RCC, a P1 trial of @CRISPRTX#CTX130 in #kidneycancer in the @sitcancer#PressProgram. Will present more on Thurs 5:37p at #SITC22! Thx @neerajaiims@DrBenTran@HaanenJohn#SamerSrour& co-Is! t.co/aDnhG9n92A

not rated
Shilpa Gupta
5095 Followers
Cleveland, OH
November 8, 2022
Not Rated
Tian Zhang, MD, MHS
6463 Followers
Dallas, TX
November 8, 2022

CAR-Ts are coming for #kidneycancer!! Congratulations @montypal and team; can’t wait to see results at #SITC22! t.co/9MrlF2yzBe

Not Rated
Moshe Ornstein MD
1930 Followers
Cleveland, OH
November 8, 2022

Congrats @montypal and team! Great to see CAR T therapy coming to #RCCt.co/ypRHBC89Pt

Not Rated
Shuchi Gulati MD
12476 Followers
Seattle, WA
November 8, 2022

Another huge step from none other than @montypal!! CAR-Ts in #kidneycancer!Congratulations to the entire team!Looking forward to seeing the results at #SITC22! t.co/HvKeVBPyV7

Not Rated
Petros Grivas
12476 Followers
Seattle, WA
November 8, 2022

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