ASCO GI Reaction
January 22, 2023

ASCO GI Reaction - SUNLIGHT

ASCO GI Reaction
January 23, 2023

ASCO GI Reaction - SUNLIGHT

Author

Trifluridine/tipiracil plus bevacizumab for third-line treatment of refractory metastatic colorectal cancer: The phase 3 randomized SUNLIGHT study.

Abstract # 4: Josep Tabernero presented results of the P3 SUNLIGHT trial assessing trifluridine/tipiracil (FTD/TPI) ± bevacizumab (Bev) in 492 heavily pretreated patients (pts) with metastatic colorectal cancer (mCRC)

Results:

  • FTD/TPI + Bev vs FTD/TPI:
    • Median OS: 10.8 vs 7.5 months
    • OS rates at 12 months: 43% vs 30%
    • Median PFS: 5.6 vs 2.4 months
    • Grade ≥3 AEs: 72.4% vs 69.5%
    • Dose reductions: 16% vs 12%
    • FTD/TPI-related AEs: 90% vs 81%; Bev-related AEs: 48% vs NA
    • Median time to deterioration of global health status: 8.5 vs. 4.7 months
    • No new safety signals

Thought leader reactions were positive with several lauding the OS and PS benefit seen with FTD/TPI+ Bev in heavily pre-treated mCRC and considering the combo anew standard of care.

Others noted that the results were more practice confirming than practice changing, given that many oncologists already preferred FTD/TPI + Bev.

Some commentators felt that the results prove the benefits of continued anti-angiogenesis in mCRC.

Summary:

Thought leaders welcomed these results, declaring FTD/TPI + Bev as practice-changing or -confirming and a new standard of care in heavily pre-treated mCRC patient population; the results also show the benefits of continued anti-angiogenesis in this population.

Synthesis powered by Opus Strategy LLC.

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Not rated
Allison Betof Warner, MD, PhD (she/her) 4
3743
Manhattan, NY
November 10, 2022

79% had reduction in disease. ORR 31%. Many responses deepen over time.

Not rated
Allison Betof Warner, MD, PhD (she/her) 3
3743
Manhattan, NY
November 10, 2022

Median DOR not yet reached. Median OS 13.9 mo. 12 mo OS was 54%. As typical with immunotherapy, we see a nice tail on the curve. #TIL#SITC22

Positive
Alex Shoushtari, MD
2253
New York, USA
November 10, 2022

Important work on efficacy of TIL therapy lifileucel in PD-1 resistant #melanoma being presented at #SITC22. Pretty good durability for this heavy lift of a treatment.

Not rated
Allison Betof Warner, MD, PhD (she/her) 2
3743
Manhattan, NY
November 10, 2022

Toxicity profile was in line with prior TIL/Lifileucel data. No surprises here. Median # doses of IL-2 was 6.

Positive
Hussein Tawbi, MD, PhD
1685
Houston, TX
November 10, 2022

Absolutely agree!… this should be available to our melanoma patients ASAP!… and paves the way for smarter cellular therapies to be designed, studied, and eventually widely disseminated

Positive
Allison Betof Warner, MD, PhD (she/her) 1
3744
Manhattan, NY
November 10, 2022

Where does this leave us with #TIL therapy for #melanoma? IMO, this response rate/durability justifies accelerated approval. Pts with PD-1 refractory melanoma need options. It’s FAR from a perfect tx but provides meaningful clinical benefit. What say you melanoma Twitterverse?

Not Rated
Sumanta K. Pal, MD, FASCO
15083 Followers
Los Angeles, CA
November 8, 2022

Just before I start AM clinic at @cityofhopeoc, excited to share results from #COBALT_RCC, a P1 trial of @CRISPRTX#CTX130 in #kidneycancer in the @sitcancer#PressProgram. Will present more on Thurs 5:37p at #SITC22! Thx @neerajaiims@DrBenTran@HaanenJohn#SamerSrour& co-Is! t.co/aDnhG9n92A

not rated
Shilpa Gupta
5095 Followers
Cleveland, OH
November 8, 2022
Not Rated
Tian Zhang, MD, MHS
6463 Followers
Dallas, TX
November 8, 2022

CAR-Ts are coming for #kidneycancer!! Congratulations @montypal and team; can’t wait to see results at #SITC22! t.co/9MrlF2yzBe

Not Rated
Moshe Ornstein MD
1930 Followers
Cleveland, OH
November 8, 2022

Congrats @montypal and team! Great to see CAR T therapy coming to #RCCt.co/ypRHBC89Pt

Not Rated
Shuchi Gulati MD
12476 Followers
Seattle, WA
November 8, 2022

Another huge step from none other than @montypal!! CAR-Ts in #kidneycancer!Congratulations to the entire team!Looking forward to seeing the results at #SITC22! t.co/HvKeVBPyV7

Not Rated
Petros Grivas
12476 Followers
Seattle, WA
November 8, 2022

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